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Dec 10, 2024 | 
medrxiv.org | Takashi Shimoyama |Koichi Matsuda |Yoichiro Kamatani |Hiroki Yamaguchi
The authors have declared no competing interest. N/AThis work was supported by a Grant-in-Aid for Scientific Research (C) (21K07445) from Japan Society for the Promotion of Science (JSPS). I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
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Aug 29, 2024 | 
nature.com | Ikuo Otsuka |Toshiyuki Shirai |Xiaoxi Liu |Yoichiro Kamatani |Chikashi Terao
AbstractMosaic chromosomal alterations (mCAs) are classified as mosaic deletions (loss), copy-neutral loss of heterozygosity (CN-LOH), and duplications (gain), attracting special attention as biological aging-related acquired genetic alterations. While these mCAs have been linked with aging and various diseases, no study has investigated their association with suicide risk which is associated with abnormal biological aging.
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Aug 26, 2024 | 
nature.com | Yoichiro Kamatani |Tadashi Kaname
Artificial intelligence (AI) and machine learning (ML) are rapidly growing and becoming essential research tools in the world of science. Genetics is no exception, and many approaches have been developed to incorporate a variety of these techniques.
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Jul 23, 2024 | 
nature.com | Wei Gan |Robert Clarke |Masaru Koido |Masahiro Kanai |Yukinori Okada |Yoichiro Kamatani | +7 more
AbstractElevated blood pressure (BP) is major risk factor for cardiovascular diseases (CVD). Genome-wide association studies (GWAS) conducted predominantly in populations of European ancestry have identified >2,000 BP-associated loci, but other ancestries have been less well-studied. We conducted GWAS of systolic, diastolic, pulse, and mean arterial BP in 100,453 Chinese adults. We identified 128 non-overlapping loci associated with one or more BP traits, including 74 newly-reported associations.
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Jul 15, 2024 | 
nature.com | Yoichiro Kamatani |Jun Sese |Shuji Kawaguchi
AbstractGenome-wide association studies have enabled the identification of important genetic factors in many trait studies. However, only a fraction of the heritability can be explained by known genetic factors, even in the most common diseases.
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Jun 26, 2024 | 
mdpi.com | Toshihiko Matsuo |Yoichiro Kamatani |Takahisa Kawaguchi |Ichiro Hamasaki
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Jun 17, 2024 | 
medrxiv.org | Yoichiro Kamatani |Biobank Japan |Naoki Kojima |Masaru Koido
Y.K. holds stock of Staten Co., Ltd. This research was supported by the Ministry of Education, Culture, Sports, Sciences and Technology (MEXT) of the Japanese government and the Japan Agency for Medical Research and Development (AMED) under grant nos. JP18km0605001/ JP23tm0624002 (the BioBank Japan project), JP223fa627011 (Y.K.), and JP23tm0524003 (Y.K.). I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
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Jun 11, 2024 | 
nature.com | Shinichi Namba |Ken Suzuki |Kenichi Yamamoto |Kyuto Sonehara |Akira Narita |Yoichiro Kamatani | +3 more
AbstractType 2 diabetes (T2D) shows heterogeneous body mass index (BMI) sensitivity. Here, we performed stratification based on BMI to optimize predictions for BMI-related diseases. We obtained BMI-stratified datasets using data from more than 195,000 individuals (nT2D = 55,284) from BioBank Japan (BBJ) and UK Biobank. T2D heritability in the low-BMI group was greater than that in the high-BMI group.
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Nov 30, 2023 | 
nature.com | Yoichiro Kamatani
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Aug 23, 2023 | 
nature.com | Yuki Ishikawa |Rosalind A. Eeles |Yoshinao Koike |Keiko Hikino |Momoko Horikoshi |Kaoru Ito | +4 more
AbstractProstate cancer (PrCa) is the second most common cancer worldwide in males. While strongly warranted, the prediction of mortality risk due to PrCa, especially before its development, is challenging.
