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Apr 10, 2024 | 
biorxiv.org | Christian Montès |Jingyuan Zhang |Trevor M. Nolan |Justin Walley
AbstractRecently, major advances have enabled the exploration of cellular heterogeneity using single-cell proteomics. Here we explore the feasibility of single-cell proteomics on plant samples. We focus on Arabidopsis thaliana, examining isolated single cells from the cortex and endodermis, which are two adjacent root cell-types derived from a common stem cell. From 756 cells we identify 3,751 proteins and 1,114 proteins/cell.
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Mar 30, 2023 | 
science.org | Trevor M. Nolan |Moiré photonics |Luojun Du |Qiang Feng
Elevating Wacker to a higher stateWacker oxidation uses palladium catalysis to produce aldehydes or ketones from olefins and water. The generally accepted mechanism relies on a hydride migration, which is not possible in geminally disubstituted olefins, which lack the requisite hydrogen. Feng et al. report a method to promote carbon migration in this class of substrates by oxidizing a catalyst intermediate to the PdIV state.
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Mar 30, 2023 | 
science.org | Trevor M. Nolan |Moiré photonics |Luojun Du |Thomas Cullen
Not a toothy grinTheropod dinosaurs such as the iconic Tyrannosaurus rex have long been portrayed with their teeth fully visible, similar to extant crocodilians. This pattern of portrayal largely had to do with relatedness between dinosaurs and crocodilians and the relationship between tooth and jaw size. Cullen et al.
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Mar 30, 2023 | 
science.org | Trevor M. Nolan |Moiré photonics |Luojun Du |Barbara U. Schraml
(0)eLetters eLetters is a forum for ongoing peer review. eLetters are not edited, proofread, or indexed, but they are screened. eLetters should provide substantive and scholarly commentary on the article. Embedded figures cannot be submitted, and we discourage the use of figures within eLetters in general. If a figure is essential, please include a link to the figure within the text of the eLetter. Please read our Terms of Service before submitting an eLetter. Log In to Submit a Response
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Mar 30, 2023 | 
science.org | Trevor M. Nolan |Moiré photonics |Luojun Du |Rodrigo Gonzalez |
Nociceptors and dendritic cells tangoNociceptors are afferent neurons that transmit pain and itch sensations in response to noxious stimuli. Although they can influence dendritic cells (DCs), the specifics of nociceptor–DC cross-talk have been unclear. Hanč et al. found that nociceptors can control DC functions in at least three ways that are context dependent (see the Perspective by Schraml). Nociceptors can attract DCs to tissues and regulate how long they stay there through the chemokine CCL21.
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Mar 30, 2023 | 
science.org | Trevor M. Nolan |Moiré photonics |Luojun Du |Duncan Palmer
Dominance in the BiobankAccording to classical genetics, traits are usually divided into dominant and recessive, with all-or-none phenotypes. Such binary traits are often observed in plant and animal breeding, but they are rarely seen in human studies outside of monogenic disorders with Mendelian inheritance patterns. Instead, many traits included in human genomic studies exhibit additive effects based on gene dosage. Palmer et al.
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Mar 30, 2023 | 
science.org | Trevor M. Nolan |Moiré photonics |Luojun Du |Rob Dunn
(0)eLetters eLetters is a forum for ongoing peer review. eLetters are not edited, proofread, or indexed, but they are screened. eLetters should provide substantive and scholarly commentary on the article. Embedded figures cannot be submitted, and we discourage the use of figures within eLetters in general. If a figure is essential, please include a link to the figure within the text of the eLetter. Please read our Terms of Service before submitting an eLetter. Log In to Submit a Response
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Mar 30, 2023 | 
science.org | Trevor M. Nolan |Moiré photonics |Luojun Du |Maddy Seale |Brad Wible
Plant Science Splitting hairsMaddy SealeThe leaves and shoots of tomato plants produce seven types of hairs, which can be grouped into digitate (finger-like) trichomes and peltate (shield-shaped) trichomes bearing multicellular glands. Wu et al. found that the concentration of a transcription factor called Woolly regulates the differentiation of trichomes.
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Mar 30, 2023 | 
science.org | Trevor M. Nolan |Moiré photonics |Luojun Du |Michael Smith |Michaël Smith
All fiber fluidicsFibers are the basis of ropes and fabrics. With the development of advanced fibers that can act as sensors and actuators or store or harvest energy, it is possible to make fabrics with advanced functionalities. Smith et al. show that it is also possible to design fibers to pump fluids, a task otherwise left to external, bulky devices. Helical electrodes are first embedded into the walls of a tubular fiber.
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Mar 30, 2023 | 
science.org | Trevor M. Nolan |Moiré photonics |Luojun Du |Giuseppe Matarese
Compelling epidemiological evidence reveals a strong association between being overweight or obese and the risk of developing autoimmune diseases (1). From an immunological standpoint, the cellular and molecular mechanisms linked to this association include the overstimulation of T lymphocytes by nutrient- and energy-sensing pathways. The immunometabolic state of an individual is central to the modulation of immunological self-tolerance that suppresses self-reactivity to avoid autoimmunity.
