Tripti Kharbanda

Nov 18, 2024 | biorxiv.org | Tripti Kharbanda |Michelle D'souza |Dasaradhi Palakodeti |Ravi S Muddashetty

AbstractFragile X Messenger Ribonucleoprotein 1 (FMRP) is a multifunctional, multidomain RNA-binding protein whose loss causes Fragile X syndrome. It is also known to associate with ribosomes and modulate translation. In human embryonic stem cells (hESCs), knockout (KO) of the FMR1 gene results in significantly increased protein translation rates and alterations in the 2′-O-methylation patterns of rRNA.