Tuan D. Samdin

5 days ago | dx.doi.org | Tuan D. Samdin |Jacek Lubkowski |Caleb Anderson |Joel Schneider

Dec 8, 2023 | pubs.rsc.org | Tuan D. Samdin |Chelsea Jones |Gretchen Guaglianone |Adam G Kreutzer

A β-barrel-like tetramer formed by a β-hairpin derived from Aβ† β-Hairpins formed by the β-amyloid peptide Aβ are building blocks of Aβ oligomers. Three different alignments of β-hairpins have been observed in the structures of Aβ oligomers or fibrils. Differences in β-hairpin alignment likely contribute to the heterogeneity of Aβ oligomers and thus impede their study at high-resolution.