Tuan Dilshad Samdin

Nov 28, 2023 | pubs.rsc.org | Chelsea Jones |Gretchen Guaglianone |Adam G Kreutzer |Tuan Dilshad Samdin

A β-Barrel-Like Tetramer Formed by a β-Hairpin Derived From Aβ β-Hairpins formed by the β-amyloid peptide Aβ are building blocks of Aβ oligomers. Three different alignments of β-hairpins have been observed in the structures of Aβ oligomers or fibrils. Differences in β-hairpin alignment likely contribute to the heterogeneity of Aβ oligomers and thus impede their study at high-resolution.