Uros Kuzmanov

May 6, 2024 | nature.com | Homaira Hamidzada |Uros Kuzmanov |Renee Gorman |Michael Atkins |Babak Razani |Ana Andreazza | +2 more

AbstractYolk sac macrophages are the first to seed the developing heart; however, owing to a lack of accessible tissue, there is no understanding of their roles in human heart development and function. In this study, we bridge this gap by differentiating human embryonic stem (hES) cells into primitive LYVE1+ macrophages (hESC-macrophages) that stably engraft within contractile cardiac microtissues composed of hESC-cardiomyocytes and fibroblasts.