Renee Gorman

May 6, 2024 | nature.com | Homaira Hamidzada |Uros Kuzmanov |Renee Gorman |Michael Atkins |Babak Razani |Ana Andreazza | +2 more

AbstractYolk sac macrophages are the first to seed the developing heart; however, owing to a lack of accessible tissue, there is no understanding of their roles in human heart development and function. In this study, we bridge this gap by differentiating human embryonic stem (hES) cells into primitive LYVE1+ macrophages (hESC-macrophages) that stably engraft within contractile cardiac microtissues composed of hESC-cardiomyocytes and fibroblasts.

Feb 6, 2024 | physoc.onlinelibrary.wiley.com | Renee Gorman |Simona Yakobov |Nazari Polidovitch |Ryan Debi

Introduction International guidelines recommend 150 min of moderate physical activity (PA) or 75 min of high-intensity exercise per week for optimal health outcomes (Singh et al., 2020). The benefits of regular exercise are broad, ranging from reduced metabolic disorders (Carbone et al., 2019), lower incidence of selected cancers (Rezende et al., 2018) and improved cardiorespiratory health (Swain, 2005), even in patients with cardiovascular-related diseases (Fiuza-Luces et al., 2018).