Vahid Rahmati

Apr 13, 2023 | nn.neurology.org | Sarosh R Irani |Andreas Ritzau-Jost |Vahid Rahmati |Marin Kempfer

LRR-Specific Antibodies Enhance Initial Firing and Spike-Frequency Adaptation Kv1 channels mediate a slowly inactivating K+ current (ID), which can effectively regulate the early IFF of both hippocampal and cortical neurons.29,-,32 Because (1) LGI1 binding triggers a protein complex including Kv1 channels and (2) LGI1 molecules can selectively prevent Kv1 inactivation mediated by the auxiliary protein Kvβ,36 we hypothesized that mAbs that interfere with the LGI1-Kv1 complex may increase the...