Vaibhav Upadhyay

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Articles

A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity

Nov 4, 2024 | cell.com | Margaret Alexander |Vaibhav Upadhyay |Rachel Rock |Lorenzo Ramírez |Kai Trepka |Patrycja Puchalska | +10 more
A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity

Nov 3, 2023 | biorxiv.org | Margaret Alexander |Vaibhav Upadhyay |Rachel Rock |Lorenzo Ramírez

AbstractDiet can protect from autoimmune disease; however, whether diet acts via the host and/or microbiome remains unclear. Here, we use a ketogenic diet (KD) as a model to dissect these complex interactions. A KD rescued the experimental autoimmune encephalomyelitis (EAE) mouse model of multiple sclerosis in a microbiota-dependent fashion.

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