Margaret Alexander

Nov 4, 2024 | cell.com | Margaret Alexander |Vaibhav Upadhyay |Rachel Rock |Lorenzo Ramírez |Kai Trepka |Patrycja Puchalska | +10 more

Apr 22, 2024 | biorxiv.org | Richard H. Chapple |Xueying Liu |Sivaraman Natarajan |Margaret Alexander

AbstractNeuroblastoma is a common pediatric cancer, where preclinical studies suggest that a mesenchymal-like gene expression program contributes to chemotherapy resistance. However, clinical outcomes remain poor, implying we need a better understanding of the relationship between patient tumor heterogeneity and preclinical models. Here, we generated single-cell RNA-seq maps of neuroblastoma cell lines, patient-derived xenograft models (PDX), and a genetically engineered mouse model (GEMM).

Nov 3, 2023 | biorxiv.org | Margaret Alexander |Vaibhav Upadhyay |Rachel Rock |Lorenzo Ramírez

AbstractDiet can protect from autoimmune disease; however, whether diet acts via the host and/or microbiome remains unclear. Here, we use a ketogenic diet (KD) as a model to dissect these complex interactions. A KD rescued the experimental autoimmune encephalomyelitis (EAE) mouse model of multiple sclerosis in a microbiota-dependent fashion.

Apr 14, 2023 | biorxiv.org | Richard H. Chapple |Xueying Liu |Sivaraman Natarajan |Margaret Alexander

AbstractNeuroblastoma is a common pediatric cancer, where preclinical studies have suggested chemotherapy resistance is driven by a mesenchymal-like gene expression program. However, the poor clinical outcomes imply we need a better understanding of the relationship between patient tumors and preclinical models. Here, we generated single-cell RNA-seq maps of neuroblastoma cell lines, patient-derived xenograft models (PDX), and a genetically engineered mouse model (GEMM).