Valerie Horsley

Oct 25, 2024 | elifesciences.org | Valerie Horsley |Nathaniel Meyer |Dianyuan Zhao |Aya Nasserdine

Before an embryo implants itself into the uterine wall, the stem cells it contains exist in a primitive ‘naïve’ pluripotent state from which they can develop into any cell type in the future body. After implantation, however, these cells transition to a primed pluripotent state where they exhibit more limited potential with each cell only being able to adopt a few predetermined fates. Once primed, the cells then differentiate into the multiple lineages of a developing embryo.

Sep 10, 2024 | timeshighereducation.com | Valerie Horsley

Science is hard. At the bench, even the simplest procedures, such as cloning or genotyping, can – and likely will – fail at some point. Projects take years to complete. Grant proposals are rejected. Paper submissions get barely a glance from editors, and if they do go out for review, long lists of additional experiments are often requested by anonymous peers. It is rare to get positive feedback on your work when it is constantly viewed through the critical lens of scientific enquiry.

Aug 13, 2024 | biorxiv.org | Diane King |Valerie Horsley

AbstractDefects in apoptotic cell clearance, or efferocytosis, can cause inflammatory diseases and prevent tissue repair due in part to inducing a pro-repair transcriptional program in phagocytic cells like macrophages.