Dianyuan Zhao

Oct 25, 2024 | elifesciences.org | Dianyuan Zhao |Ziwei Huang |Xiaoyu Li |Huan Wang

eLife Assessment This valuable study delineates the cellular contributions of BMP signaling in liver development and function. The findings are convincing, and the study employs state-of-the-art molecular, genetic, and cellular approaches to demonstrate that hepatic stellate cells play a central role in liver health by mediating cell-to-cell crosstalk via the production of specific BMP proteins.

Oct 25, 2024 | elifesciences.org | Valerie Horsley |Nathaniel Meyer |Dianyuan Zhao |Aya Nasserdine

Before an embryo implants itself into the uterine wall, the stem cells it contains exist in a primitive ‘naïve’ pluripotent state from which they can develop into any cell type in the future body. After implantation, however, these cells transition to a primed pluripotent state where they exhibit more limited potential with each cell only being able to adopt a few predetermined fates. Once primed, the cells then differentiate into the multiple lineages of a developing embryo.

Feb 9, 2024 | biorxiv.org | Dianyuan Zhao |Ziwei Huang |Xiaoyu Li |Huan Wang

AbstractThe liver is the largest solid organ in the body and is primarily composed of HCs, ECs, KCs, and HSCs, which spatially interact and cooperate with each other to maintain liver homeostasis. However, the complexity and molecular mechanisms underlying the crosstalk between these different cell types remain to be revealed. Here, we generated mice with conditional deletion of Bmp9/10 in different liver cell types and demonstrated that HSCs were the major source of BMP9 and BMP10 in the liver.