van Wijk

Nov 19, 2024 | academic.oup.com | location AMC |Van Schaik |van Royen-Kerkhof |van Wijk

Novel biomarkers are needed to guide therapy in idiopathic inflammatory myopathies (IIM). Expression of Siglec-1, a type I interferon biomarker, was examined in adult patients with IIM in relation to disease activity and treatment response. We analysed PBMC samples from 19 newly diagnosed adult IIM patients who participated in a phase-2 pilot study on efficacy of intravenous immunoglobulin (IVIG) monotherapy, and from 9 healthy controls.

Aug 18, 2024 | academic.oup.com | van Wijk

The chloroplast chaperone CLPC1 aids to select, unfold and deliver hundreds of proteins to the CLP protease for degradation. Through in vivo CLPC1 trapping we previously identified dozens of proteins that are (potential) substrate adaptors or substrates for the CLP chaperone-protease system. Here we show that two of these highly trapped proteins, DUF760-1 and DUF760-2, are substrates for the CLP protease in Arabidopsis (Arabidopsis thaliana).

Feb 12, 2024 | zenodo.org | van Wijk

Methods Chloridea (Heliothis) virescens populationsoriginated from North Carolina State University (YDK strain) and the Max Planck Institute for Chemical Ecology, Jena, and have been reared at the Institute for Biodiversity and Ecosystem and Dynamics (IBED), University of Amsterdam since 2011. We conducted the experiment for this study between April 2018 and November 2019.

Dec 19, 2023 | arxiv.org | van Wijk

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Aug 4, 2023 | arxiv.org | van Wijk

This paper investigates the problem of on-orbit spacecraft inspection using a single free-flying deputy spacecraft, equipped with an optical sensor, whose controller is a neural network control system trained with Reinforcement Learning (RL). This work considers the illumination of the inspected spacecraft (chief) by the Sun in order to incentivize acquisition of well-illuminated optical data.