Vasundhara Singh

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BACH2 regulates diversification of regulatory and proinflammatory chromatin states in TH17 cells - Nature Immunology

Jul 15, 2024 | nature.com | Alexandra Schnell |Maryann Zhao |Elena Christian |Sarah Zaghouani |Vasundhara Singh |Anvita Singaraju | +6 more

AbstractInterleukin-17 (IL-17)-producing helper T (TH17) cells are heterogenous and consist of nonpathogenic TH17 (npTH17) cells that contribute to tissue homeostasis and pathogenic TH17 (pTH17) cells that mediate tissue inflammation. Here, we characterize regulatory pathways underlying TH17 heterogeneity and discover substantial differences in the chromatin landscape of npTH17 and pTH17 cells both in vitro and in vivo.

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