Alexandra Schnell

Jul 15, 2024 | nature.com | Alexandra Schnell |Maryann Zhao |Elena Christian |Sarah Zaghouani |Vasundhara Singh |Anvita Singaraju | +6 more

AbstractInterleukin-17 (IL-17)-producing helper T (TH17) cells are heterogenous and consist of nonpathogenic TH17 (npTH17) cells that contribute to tissue homeostasis and pathogenic TH17 (pTH17) cells that mediate tissue inflammation. Here, we characterize regulatory pathways underlying TH17 heterogeneity and discover substantial differences in the chromatin landscape of npTH17 and pTH17 cells both in vitro and in vivo.

May 28, 2024 | onlinelibrary.wiley.com | Alexandra Schnell

CONFLICT OF INTEREST STATEMENT Alexandra Schnell has no conflict of interest to report. REFERENCES 1, , , , . T cells in health and disease. Signal Transduct Target Ther. 2023; 8: 235. doi:10.1038/s41392-023-01471-y 2, . T lymphocytes and autoimmunity. Int Rev Cell Mol Biol. 2018; 341: 125-168. doi:10.1016/bs.ircmb.2018.05.008 3, , . The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy. Nat Rev Cancer. 2020; 20: 662-680. doi:10.1038/s41568-020-0285-7 4, , .

Jun 21, 2023 | nature.com | Yoon-Chul Kye |Elena Torlai Triglia |Alexandra Schnell |Toni Delorey |Kanishka Mohib |Christopher J. Giuliano | +11 more

AbstractThe role of B cells in anti-tumour immunity is still debated and, accordingly, immunotherapies have focused on targeting T and natural killer cells to inhibit tumour growth1,2. Here, using high-throughput flow cytometry as well as bulk and single-cell RNA-sequencing and B-cell-receptor-sequencing analysis of B cells temporally during B16F10 melanoma growth, we identified a subset of B cells that expands specifically in the draining lymph node over time in tumour-bearing mice.