Veerababurao Kavala

Apr 25, 2023 | pubs.acs.org | Li-Chun Lin |Veerababurao Kavala |Sundaram Suresh |Kun-Wu Lin

We report on a copper-catalyzed three-component reaction for the synthesis of disubstituted nicotinonitriles using 3-bromopropenals, benzoylacetonitriles, and ammonium acetate (NH4OAc). The Knoevenagel-type condensation of 3-bromopropenals with benzoylacetonitriles gives δ-bromo-2,4-dienones that contain strategically placed functional groups that react with the ammonia generated in situ to give the corresponding azatrienes.