Li-Chun Lin

Jun 25, 2024 | 4hoteliers.com | Richard Whitfield |Li-Chun Lin |Gert Noordzy |Liberty Chirumiko

 SHARE THIS PAGE NEWSLETTERS CONTACT USSUBMIT CONTENTADVERTISING Developing the Huma Island Resort and SpaBy Richard Whitfield, Li-Chun Lin, Gert Noordzy, Liberty ChirumikoWednesday, 26th June 2024 Building construction accounts for a large part of the cost of developing any new hotel, but it is only part of the process that must be worked through to establish and launch the property.

Jun 18, 2024 | 4hoteliers.com | Richard Whitfield |Li-Chun Lin |Gert Noordzy |Liberty Chirumiko

 SHARE THIS PAGE NEWSLETTERS CONTACT USSUBMIT CONTENTADVERTISING Developing the Songtsam Laigu LodgeBy Richard Whitfield, Li-Chun Lin, Gert Noordzy, Liberty ChirumikoTuesday, 18th June 2024 Building construction accounts for a large part of the cost of developing any new hotel, but it is only part of the process that must be worked through to establish and launch the property.

Nov 4, 2023 | nature.com | Yann Vanrobaeys |Zeru Peterson |Snehajyoti Chatterjee |Li-Chun Lin |Thomas Nickl-Jockschat |Ted Abel | +2 more

Sleep deprivation has far-reaching consequences on the brain and behavior, impacting memory, attention, and metabolism. Previous research has focused on gene expression changes in individual brain regions, such as the hippocampus or cortex. Therefore, it is unclear how uniformly or heterogeneously sleep loss affects the brain. Here, we use spatial transcriptomics to define the impact of a brief period of sleep deprivation across the brain in male mice. We find that sleep deprivation induced pronounced differences in gene expression across the brain, with the greatest changes in the hippocampus, neocortex, hypothalamus, and thalamus. Both the differentially expressed genes and the direction of regulation differed markedly across regions. Importantly, we developed bioinformatic tools to register tissue sections and gene expression data into a common anatomical space, allowing a brain-wide comparison of gene expression patterns between samples. Our results suggest that distinct molecular mechanisms acting in discrete brain regions underlie the biological effects of sleep deprivation. Sleep deprivation impacts molecular changes across brain regions. Here, the authors utilize a spatial. transcriptomics approach to elucidate acute sleep deprivation-induced gene expression signature. across regions and subregions of the brain.

Apr 25, 2023 | pubs.acs.org | Li-Chun Lin |Veerababurao Kavala |Sundaram Suresh |Kun-Wu Lin

We report on a copper-catalyzed three-component reaction for the synthesis of disubstituted nicotinonitriles using 3-bromopropenals, benzoylacetonitriles, and ammonium acetate (NH4OAc). The Knoevenagel-type condensation of 3-bromopropenals with benzoylacetonitriles gives δ-bromo-2,4-dienones that contain strategically placed functional groups that react with the ammonia generated in situ to give the corresponding azatrienes.