Veronika Kudrina

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Articles

Lysosomal TMEM165 controls cellular ion homeostasis and survival by mediating lysosomal Ca2+ import and H+ efflux - Nature Communications

3 weeks ago | nature.com | Ran Chen |Bin Liu |Veronika Kudrina |Yvonne E. Klingl |Arnas Petrauskas |Sandra Castro | +2 more

AbstractThe proper function of lysosomes depends on their ability to store and release calcium. While several lysosomal calcium release channels have been described, how lysosomes replenish their calcium stores in placental mammals has not been determined.
Rab7a is an enhancer of TPC2 activity regulating melanoma progression through modulation of the GSK3β/β-Catenin/MITF-axis - Nature Communications

Nov 18, 2024 | nature.com | Carla Abrahamian |Eva-Maria Weiden |Maria S. Soengas |Thomas C. Frohlich |Cheng-Chang Chen |Karin Bartel | +2 more

AbstractMelanoma arising from pigment-producing melanocytes is the deadliest form of skin cancer. Extensive ultraviolet light exposure is a major cause of melanoma and individuals with low levels of melanin are at particular risk. Humans carrying gain-of-function polymorphisms in the melanosomal/endolysosomal two-pore cation channel TPC2 present with hypopigmentation, blond hair, and albinism.

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