Veronika V. Odintsova

Nov 6, 2023 | nature.com | Fang Fang |Bryan C Quach |Jesse Marks |Veronika V. Odintsova |Yujing Xia |Laura J. Bierut | +7 more

AbstractCannabis is widely used worldwide, yet its links to health outcomes are not fully understood. DNA methylation can serve as a mediator to link environmental exposures to health outcomes. We conducted an epigenome-wide association study (EWAS) of peripheral blood-based DNA methylation and lifetime cannabis use (ever vs. never) in a meta-analysis including 9436 participants (7795 European and 1641 African ancestry) from seven cohorts.

May 15, 2023 | nature.com | Dmitry Kuznetsov |Fiona A. Hagenbeek |Jana S. Hirzinger |Sophie Breunig |Susanne Bruins |Kirsten Schut | +1 more

Classic twin designThe classical twin design compares the resemblance of MZ and DZ twins for univariate or multivariate traits to estimate heritability and genetic correlations among phenotypes (a glossary of key terms is provided in Box 1).