Vihang A. Narkar

Oct 10, 2024 | digitalcommons.library.tmc.edu | Vihang A. Narkar

AbstractExercise has a profound effect on cardiovascular disease, particularly through vascular remodeling and regeneration. Peripheral artery disease (PAD) is one such cardiovascular condition that benefits from regular exercise or rehabilitative physical therapy in terms of slowing the progression of disease and delaying amputations. Various rodent pre-clinical studies using models of PAD and exercise have shed light on molecular pathways of vascular regeneration.

Oct 10, 2024 | digitalcommons.library.tmc.edu | Anirban Roy |Vihang A. Narkar |Ashok Kumar

AbstractMaintenance of skeletal muscle mass and strength throughout life is crucial for heathy living and longevity. Several signaling pathways have been implicated in the regulation of skeletal muscle mass in adults. TGF-β-activated kinase 1 (TAK1) is a key protein, which coordinates the activation of multiple signaling pathways. Recently, it was discovered that TAK1 is essential for the maintenance of skeletal muscle mass and myofiber hypertrophy following mechanical overload.

Oct 10, 2024 | digitalcommons.library.tmc.edu | Vihang A. Narkar |Anurag Singh |Luigi Ferrucci |Waly Dioh

In recent years, several new classes of therapies have been investigated with their potential for restoring or improving physical functioning in older adults. These have included Mas receptor agonists, regulators of mitophagy, skeletal muscle troponin activators, anti-inflammatory compounds, and targets of orphan nuclear receptors.

Oct 10, 2024 | digitalcommons.library.tmc.edu | Ashok Kumar |Vihang A. Narkar

AbstractPeripheral arterial disease (PAD) is a prevalent cardiovascular complication of limb vascular insufficiency, causing ischemic injury, mitochondrial metabolic damage and functional impairment in the skeletal muscle, and ultimately leading to immobility and mortality.