Vijay Ramaswamy

Sep 2, 2024 | nature.com | Edward Lee |Michelle Han |Hollie A. Lai |Kristian Aquilina |Tina Y Poussaint |Vijay Ramaswamy | +6 more

AbstractWhile multiple factors impact disease, artificial intelligence (AI) studies in medicine often use small, non-diverse patient cohorts due to data sharing and privacy issues. Federated learning (FL) has emerged as a solution, enabling training across hospitals without direct data sharing. Here, we present FL-PedBrain, an FL platform for pediatric posterior fossa brain tumors, and evaluate its performance on a diverse, realistic, multi-center cohort.

Sep 1, 2024 | flipboard.com | Edward Lee |Michelle Han |Jason Wright |Michael S. Kuwabara |Olivia Choudhury |Ujjwal Ratan | +36 more

The Arctic2 hours agoTwo Cybertrucks Drove from Florida to the Arctic Circle and It Looks Like a NightmareGizmodo - Matthew Gault • 2hThe journey is an endurance test for the embattled electric vehicle that reveals a lot about North America's shoddy charging infrastructure.

Jul 9, 2024 | nature.com | Nicholas Fernandez |Vijay Ramaswamy |Julie Bennett |Robert Siddaway |Uri Tabori

AbstractWith the success of immunotherapy in cancer, understanding the tumor immune microenvironment (TIME) has become increasingly important; however in pediatric brain tumors this remains poorly characterized. Accordingly, we developed a clinical immune-oncology gene expression assay and used it to profile a diverse range of 1382 samples with detailed clinical and molecular annotation.

Sep 19, 2023 | nature.com | Christopher Porter |Vijay Ramaswamy

AbstractSonic Hedgehog (SHH) medulloblastomas (MBs) exhibit an intermediate prognosis and extensive intertumoral heterogeneity. While SHH pathway antagonists are effective in post-pubertal patients, younger patients exhibit significant side effects, and tumors that harbor mutations in downstream SHH pathway genes will be drug resistant. Thus, novel targeted therapies are needed.