Edward Lee

2 months ago | nature.com | Cyril Pottier |Fahri Küçükali |Matt Baker |Gregory Jenkins |Cristina T. Vicente |Wouter De Coster | +55 more

AbstractFrontotemporal lobar degeneration with neuronal inclusions of the TAR DNA-binding protein 43 (FTLD-TDP) is a fatal neurodegenerative disorder with only a limited number of risk loci identified.

Jan 24, 2025 | nature.com | Kyle Coleman |Jeong Hwan Park |Hanying Yan |Isabel Barnfather |Joshua D. Rabinowitz |Yanxiang Deng | +5 more

Correction to: Nature Methods https://doi.org/10.1038/s41592-024-02574-2, published online 15 January 2025. In the version of the article initially published, the Data availability and Code availability sections were inadvertently omitted. These sections have now been included in the HTML and PDF versions of the article. About this articleColeman, K., Schroeder, A., Loth, M. et al. Author Correction: Resolving tissue complexity by multimodal spatial omics modeling with MISO. Nat Methods (2025).

Jan 15, 2025 | nature.com | Kyle Coleman |Jeong Hwan Park |Hanying Yan |Joshua D. Rabinowitz |Yanxiang Deng |Edward Lee | +5 more

AbstractSpatial molecular profiling has provided biomedical researchers valuable opportunities to better understand the relationship between cellular localization and tissue function. Effectively modeling multimodal spatial omics data is crucial for understanding tissue complexity and underlying biology.

Sep 2, 2024 | nature.com | Edward Lee |Michelle Han |Hollie A. Lai |Kristian Aquilina |Tina Y Poussaint |Vijay Ramaswamy | +6 more

AbstractWhile multiple factors impact disease, artificial intelligence (AI) studies in medicine often use small, non-diverse patient cohorts due to data sharing and privacy issues. Federated learning (FL) has emerged as a solution, enabling training across hospitals without direct data sharing. Here, we present FL-PedBrain, an FL platform for pediatric posterior fossa brain tumors, and evaluate its performance on a diverse, realistic, multi-center cohort.

Feb 7, 2024 | jneurosci.org | Jeffrey Phillips |John Robinson |David Wolk |Edward Lee

Polypathologic Associations with Gray Matter Atrophy in Neurodegenerative Disease Jeffrey S. Phillips, John L. Robinson, Katheryn A. Q. Cousins, David A. Wolk, Edward B. Lee, Corey T. McMillan, John Q. Trojanowski, Murray Grossman, David J. Irwin Journal of Neuroscience 7 February 2024, 44 (6) e0808232023; DOI: 10.1523/JNEUROSCI.0808-23.2023