Vincent van Unen

Jul 24, 2024 | nature.com | Vincent van Unen |Steven M. Chirieleison |Joshua Chan |Kathryn E Yost |Zachary M. Sellers |Howard Chang | +5 more

AbstractIn vitro models of autoimmunity are constrained by an inability to culture affected epithelium alongside the complex tissue-resident immune microenvironment. Coeliac disease (CeD) is an autoimmune disease in which dietary gluten-derived peptides bind to the major histocompatibility complex (MHC) class II human leukocyte antigen molecules (HLA)-DQ2 or HLA-DQ8 to initiate immune-mediated duodenal mucosal injury1,2,3,4.