Vittorio L. Katis

Oct 22, 2024 | cell.com | William Bradshaw |Gemma Harris |Harwell Campus |Vittorio L. Katis

Keywords ITAM kinase structure SYK ZAP-70 SAXS SH2 immune signaling crystallography FIDA Introduction Spleen tyrosine kinase (SYK), a non-receptor tyrosine kinase, plays a crucial role in signal transduction for activated immunoreceptors in both adaptive and innate immune responses.1 Beyond immunity, SYK is involved in bone development,2 platelet activation,3 cell adhesion,4 and microglial responses to amyloid beta.5,6 Given its central signaling roles in immune pathways, tight regulation of...