Vladas Oleinikovas

Aug 16, 2023 | annualreviews.org | Pablo Gainza |Vladas Oleinikovas |Thomas Ryckmans |Bernhard Fasching

INTRODUCTION Proteins levels in the cell are tightly regulated by the ubiquitin-proteasome system (UPS). Ubiquitin E3 ligases recognize specific structured and intrinsically unstructured elements (degrons) in the target protein, triggering their ubiquitination and degradation by the proteasome. This pathway can be rewired by small molecules, leading to targeted protein degradation of desired novel substrates, commonly referred as neosubstrates.

Aug 16, 2023 | annualreviews.org | Pablo Gainza |Vladas Oleinikovas |Thomas Ryckmans |Bernhard Fasching

INTRODUCTION Proteins levels in the cell are tightly regulated by the ubiquitin-proteasome system (UPS). Ubiquitin E3 ligases recognize specific structured and intrinsically unstructured elements (degrons) in the target protein, triggering their ubiquitination and degradation by the proteasome. This pathway can be rewired by small molecules, leading to targeted protein degradation of desired novel substrates, commonly referred as neosubstrates.