Vladimir Makarov

1 week ago | nature.com | Chao Wang |Jamie K Teer |Xiaoxian Liu |Timothy Chan |Vladimir Makarov |Carmen Anadon | +6 more

AbstractCell therapy with tumor-infiltrating lymphocytes (TILs) has yielded durable responses for multiple cancer types, but the causes of therapeutic resistance remain largely unknown. Here multidimensional analysis was performed on time-serial tumor and blood in a lung cancer TIL therapy trial. Using T cell receptor sequencing on both functionally expanded T cells and neoantigen-loaded tetramer-sorted T cells, we identified tumor antigen-specific T cell receptors.