Vladislav Pavlov

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Performance of glial fibrillary acidic protein (GFAP) and ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) biomarkers in predicting CT scan results and neurological outcomes in children with traumatic brain injury (BRAINI-2 paediatric study): protocol of

May 16, 2024 | bmjopen.bmj.com | Fleur Lorton |Alfonso Lagares |Vladislav Pavlov |Odile Méjan

Performance of the biomarkers to detect ICL on CT scansWe will assess the performance of GFAP and UCH-L1 to detect ICL on CT scans separately and in combination in the VIDAS TBI assay in terms of sensitivity, specificity and positive and negative predictive values. First, cut-off points for each biomarker separately and in combination will be derived from receiver operating characteristic (ROC) curves.

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