Vsevolod V. Gurevich

Jun 20, 2024 | cell.com | Vsevolod V. Gurevich |Eugenia V. Gurevich

Highlights Several branches of arrestin-mediated signaling are initiated by G-protein-coupled receptor (GPCR)-bound arrestins. Numerous other signaling functions are mediated by free arrestins, including the mutants that cannot bind GPCRs. Biased ligands and receptor barcoding by phosphorylation patterns can only affect arrestin functions that depend on their binding to GPCRs. Manipulation of receptor-independent arrestin functions requires molecules that directly act on arrestins.

May 5, 2024 | preprints.org | Vsevolod V. Gurevich

Preprint Review Version 1 This version is not peer-reviewed Version 1 : Received: 1 May 2024 / Approved: 2 May 2024 / Online: 5 May 2024 (08:33:01 CEST) Gurevich, V. Arrestins: A Small Family of Multi-functional Proteins. Preprints 2024, 2024050141. https://doi.org/10.20944/preprints202405.0141.v1 Gurevich, V. Arrestins: A Small Family of Multi-functional Proteins. Preprints 2024, 2024050141.

May 28, 2023 | onlinelibrary.wiley.com | Vsevolod V. Gurevich

IDEA TO WATCH Conformational flexibility underlies the versatility of arrestins Vsevolod V. Gurevich,  Corresponding Author Vsevolod V. Gurevich Department of Pharmacology, Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, USA Correspondence Department of Pharmacology, Vanderbilt University, Department of Pharmacology, 2200 Pierce Ave South, PRB, Rm. 417D, Nashville, TN 37232, USA.

Mar 1, 2023 | nature.com | Vsevolod V. Gurevich |Vsevolod Katritch

AbstractUnderstanding the molecular basis of arrestin-mediated regulation of GPCRs is critical for deciphering signaling mechanisms and designing functional selectivity. However, structural studies of GPCR-arrestin complexes are hampered by their highly dynamic nature. Here, we dissect the interaction of arrestin-2 (arr2) with the secretin-like parathyroid hormone 1 receptor PTH1R using genetically encoded crosslinking amino acids in live cells.