Eugenia V. Gurevich

Jun 20, 2024 | cell.com | Vsevolod V. Gurevich |Eugenia V. Gurevich

Highlights Several branches of arrestin-mediated signaling are initiated by G-protein-coupled receptor (GPCR)-bound arrestins. Numerous other signaling functions are mediated by free arrestins, including the mutants that cannot bind GPCRs. Biased ligands and receptor barcoding by phosphorylation patterns can only affect arrestin functions that depend on their binding to GPCRs. Manipulation of receptor-independent arrestin functions requires molecules that directly act on arrestins.

Jun 5, 2023 | frontiersin.org | Phung N. Thai |Jinan Wang |Eugenia V. Gurevich

Yuanqiang Li1, Boyu Li4, Wei-Dong Chen2,3* and Yan-Dong Wang1* 1State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China 2Key Laboratory of Receptors-Mediated Gene Regulation and Drug Discovery, School of Basic Medical Science, Inner Mongolia Medical University, Hohhot, China 3Key Laboratory of Receptors-Mediated Gene Regulation, School of Medicine, The People’s Hospital of Hebi, Henan University,...