Wanson Choi

Jul 26, 2023 | nature.com | Saori Sakaue |Michelle Curtis |Yang Luo |Wanson Choi |Kazuyoshi Ishigaki |Aaron Deutsch | +2 more

AbstractThe human leukocyte antigen (HLA) locus is associated with more complex diseases than any other locus in the human genome. In many diseases, HLA explains more heritability than all other known loci combined. In silico HLA imputation methods enable rapid and accurate estimation of HLA alleles in the millions of individuals that are already genotyped on microarrays.