Michelle Curtis

Nov 8, 2023 | nature.com | fan zhang |Anna Jonsson |Michelle Curtis |Maria Gutierrez-Arcelus |Javier Rangel-Moreno |Kathryne E. Marks | +18 more

AbstractRheumatoid arthritis is a prototypical autoimmune disease that causes joint inflammation and destruction1. There is currently no cure for rheumatoid arthritis, and the effectiveness of treatments varies across patients, suggesting an undefined pathogenic diversity1,2. Here, to deconstruct the cell states and pathways that characterize this pathogenic heterogeneity, we profiled the full spectrum of cells in inflamed synovium from patients with rheumatoid arthritis.

Jul 26, 2023 | nature.com | Saori Sakaue |Michelle Curtis |Yang Luo |Wanson Choi |Kazuyoshi Ishigaki |Aaron Deutsch | +2 more

AbstractThe human leukocyte antigen (HLA) locus is associated with more complex diseases than any other locus in the human genome. In many diseases, HLA explains more heritability than all other known loci combined. In silico HLA imputation methods enable rapid and accurate estimation of HLA alleles in the millions of individuals that are already genotyped on microarrays.