Weibin Xu

Jul 26, 2024 | nature.com | Lifeng Chen |Jingjing Zhang |Weibin Xu |Jiayi Chen |Yujun Tang |Si Xiong | +3 more

AbstractRespiratory syncytial virus (RSV) hijacks cholesterol or autophagy pathways to facilitate optimal replication. However, our understanding of the associated molecular mechanisms remains limited. Here, we show that RSV infection blocks cholesterol transport from lysosomes to the endoplasmic reticulum by downregulating the activity of lysosomal acid lipase, activates the SREBP2–LDLR axis, and promotes uptake and accumulation of exogenous cholesterol in lysosomes.