Lifeng Chen

Nov 6, 2024 | mdpi.com | Jianping Wu |Lifeng Chen |Siyuan Fang |Chunming Wu

1. IntroductionAPIs, as crucial channels for functional invocations and data flows between applications, have significantly facilitated digital development, with their numbers experiencing exponential growth in recent years. However, due to their openness, APIs have increasingly become a prime target for abuse and hacking attacks, leading to many data breaches.

Sep 27, 2024 | mdpi.com | Ping Zhang |Hongling Wang |Lifeng Chen |Wenlong Li

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Jul 26, 2024 | nature.com | Lifeng Chen |Jingjing Zhang |Weibin Xu |Jiayi Chen |Yujun Tang |Si Xiong | +3 more

AbstractRespiratory syncytial virus (RSV) hijacks cholesterol or autophagy pathways to facilitate optimal replication. However, our understanding of the associated molecular mechanisms remains limited. Here, we show that RSV infection blocks cholesterol transport from lysosomes to the endoplasmic reticulum by downregulating the activity of lysosomal acid lipase, activates the SREBP2–LDLR axis, and promotes uptake and accumulation of exogenous cholesterol in lysosomes.