Weifeng Tian

Aug 9, 2024 | science.org | Yuwei Wang |Xinyu Li |Pawel Trzaskoma |Weifeng Tian

AbstractThe development of noninvasive approaches to precisely control neural activity in mammals is highly desirable. Here, we used the ion channel transient receptor potential ankyrin-repeat 1 (TRPA1) as a proof of principle, demonstrating remote near-infrared (NIR) activation of endogenous neuronal channels in mice through an engineered nanoagonist. This achievement enables specific neurostimulation in nongenetically modified mice.