Weiyi Tan

Sep 24, 2024 | pubs.rsc.org | Jiaqi Guo |Weiyi Tan |Bing Xu

Enzymatic Self-Assembly of Short Peptides for Cell Spheroid Formation Cell spheroids, including organoids, serve as a valuable bridge between in vitro systems and in vivo animal models, offering powerful tools for studying cell biology in a three-dimensional environment. However, existing methods for generating cell spheroids are time-consuming or difficult to scale up for large-scale production.

Jul 19, 2023 | onlinelibrary.wiley.com | Jiaqi Guo |Weiyi Tan |Hongjian He |Bing Xu

Graphical Abstract Carboxy-terminal diglycine-modified succinate compounds undergo autohydrolysis at physiological pH. This process converts supramolecular assemblies from nanofibers to nanoparticles for fast cellular uptake. This approach also restores drug efficacy, promoting effective intracellular therapeutics.