Bing Xu

Nov 25, 2024 | biorxiv.org | Bing Xu |Levi Legler |Tara Keshavarz Shirazi |Sereene Kurzum

AbstractRASopathies are rare genetic disorders caused by mutations in genes within the canonical Ras/MAPK signaling pathway, affecting cell growth and differentiation. These syndromes, which include conditions like Noonan syndrome (NS), are characterized by developmental delays, distinctive facial dysmorphia, and a variety of cardiac defects, notably hypertrophic cardiomyopathy (HCM). Despite their prevalence and impact, therapeutic options for RASopathies remain limited.

Nov 5, 2024 | tandfonline.com | Qianyu Chen |Zhaoyue Dong |Bing Xu |Yingxiong Ma

Two previously undescribed triterpenoids, herpetosin A (1) and herpetosin B (2), together with two known compounds, cucurbitacin B (3) and dihydrocucurbitacin E (4), were isolated from the seeds of Herpetospermum pedunculosum. Their structures were elucidated by analysis of the NMR, HR-ESI-MS, X-ray data and quantum chemical calculation. Compound 1 featured an unprecedented nor-cucurbitane triterpenoid skeleton with a 5/6/6/5 ring system.

Oct 12, 2024 | mdpi.com | Bing Xu |Lang Wang |Qin Liu |Rui Wang

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Oct 1, 2024 | mdpi.com | Kang Zhou |Chunju Zhang |Bing Xu |Jianwei Huang

1. IntroductionIn recent years, with the continuous development of internet technology and big data, people’s functional demands have evolved from merely detecting past events to real-time monitoring and further to predicting future occurrences [1,2,3,4,5]. By analyzing vast amounts of data, it is possible to predict the likelihood of events occurring, helping decision makers formulate practical plans and avoid one-sidedness and errors in decision making.

Sep 24, 2024 | pubs.rsc.org | Jiaqi Guo |Weiyi Tan |Bing Xu

Enzymatic Self-Assembly of Short Peptides for Cell Spheroid Formation Cell spheroids, including organoids, serve as a valuable bridge between in vitro systems and in vivo animal models, offering powerful tools for studying cell biology in a three-dimensional environment. However, existing methods for generating cell spheroids are time-consuming or difficult to scale up for large-scale production.