Wen Hu

Aug 11, 2024 | mdpi.com | Nan Zhang |Wen Hu

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Apr 9, 2024 | nature.com | Wen Hu |Mark Diekhans |Jordan Marrocco |Lishomwa C. Ndhlovu |Teresa A. Milner |Erich D. Jarvis | +3 more

AbstractRNA isoforms influence cell identity and function. However, a comprehensive brain isoform map was lacking. We analyze single-cell RNA isoforms across brain regions, cell subtypes, developmental time points and species. For 72% of genes, full-length isoform expression varies along one or more axes. Splicing, transcription start and polyadenylation sites vary strongly between cell types, influence protein architecture and associate with disease-linked variation.

Dec 9, 2023 | onlinelibrary.wiley.com | Kexin Liu |Ze Chen |Wen Hu |Dan Xu

CONFLICT OF INTEREST STATEMENT The authors declare that there are no conflicts of interest. REFERENCES 1, , , , . Cholesterol-induced toxicity: an integrated view of the role of cholesterol in multiple diseases. Cell Metab. 2021; 33(10): 1911-1925. doi:10.1016/j.cmet.2021.09.001 2, , , , . Global epidemiology of dyslipidaemias. Nat Rev Cardiol. 2021; 18(10): 689-700. doi:10.1038/s41569-021-00541-4 3 Organization W H. EN NMH 2012: members_states_meeting.