Wen Qin

Jan 5, 2025 | nature.com | Wen Qin

AbstractPlasma biomarkers have great potential in the screening, diagnosis, and monitoring of Alzheimer’s disease (AD). However, findings on their associations with cerebral perfusion and structural changes are inconclusive. We examined both cross-sectional and longitudinal associations between plasma biomarkers and cerebral blood flow (CBF), gray matter (GM) volume, and white matter (WM) integrity.

Dec 15, 2024 | mdpi.com | Wen Qin

Open AccessArticle by Yiran Wang 1,2, Bin Li 3, Bo Xu 3 and Wen Qin 1,* 1State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining 810016, China 2School of Ecological and Environmental Engineering, Qinghai University, Xining 810016, China 3Key Laboratory of Adaptation and Evolution of Plateau Biota, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, China *Author to whom correspondence should be addressed.

Aug 30, 2024 | nature.com | Bin Zhang |Wen Qin

AbstractPrevious research has established associations between amygdala functional connectivity abnormalities and major depressive disorder (MDD). However, inconsistencies persist due to limited sample sizes and poorly elucidated transcriptional patterns. In this study, we aimed to address these gaps by analyzing a multicenter magnetic resonance imaging (MRI) dataset consisting of 210 first-episode, drug-naïve MDD patients and 363 age- and sex-matched healthy controls (HC).

Feb 15, 2024 | nature.com | Chao Zhou |Wen Qin

AbstractDeficit schizophrenia (DS) is a subtype of schizophrenia (SCZ). The polygenic effects on the neuroimaging alterations in DS still remain unknown. This study aims to calculate the polygenic risk scores for schizophrenia (PRS-SCZ) in DS, and further explores the potential associations with functional features of brain. PRS-SCZ was calculated according to the Whole Exome sequencing and Genome-wide association studies (GWAS).

Dec 8, 2023 | jamanetwork.com | Xiaotong Li |Lihua Li |Wen Qin |Qing Cao

Key PointsQuestion  Is there an association between the urban living environment and the prevalence, incidence, progression, and severity of myopia? Findings  In this cohort study involving 177 894 elementary school students across diverse living environments, a significant association between higher urbanization levels and an increased risk of myopia incidence was found. Progression of myopia was slower and myopia was less severe in students in urban areas.