
Feng Chen
Articles
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Jan 15, 2025 |
mdpi.com | Miaoli Wang |Shaopeng Wu |Yao Wang |Feng Chen
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Oct 30, 2024 |
nature.com | Reyka G. Jayasinghe |Michael Iglesia |John Herndon |Austin N. Southard-Smith |Jacqueline L. Mudd |Alla Karpova | +16 more
AbstractTo study the spatial interactions among cancer and non-cancer cells1, we here examined a cohort of 131 tumour sections from 78 cases across 6 cancer types by Visium spatial transcriptomics (ST). This was combined with 48 matched single-nucleus RNA sequencing samples and 22 matched co-detection by indexing (CODEX) samples. To describe tumour structures and habitats, we defined ‘tumour microregions’ as spatially distinct cancer cell clusters separated by stromal components.
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Sep 19, 2024 |
nature.com | Feng Chen
AbstractPrevious findings have reported the association between frailty and chronic kidney disease. However, the causality remains ambiguous. This study aimed to determine whether frailty index is causally associated with chronic kidney disease. We obtained the frailty genome-wide association study (GWAS) data and chronic kidney disease GWAS data from the FinnGen R5 (total n = 216,743; case = 3902, control = 212,841) as the exposure and outcome, respectively.
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Aug 16, 2024 |
nature.com | Feng Chen |Max Torbenson
AbstractHistorians and paleoclimatologists have long studied the connection between ecoclimatic changes and empire growth, transformation, and decline, but striking cases remain rare. Here, we introduce a tree-ring chronology from southern China to reconstruct changes in April-to-November water balance of the middle reaches of the Yangtze River over the last 464 years.
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