Wenbin Dai

Oct 21, 2024 | pubs.rsc.org | Jinchao Zhao |Wenbin Dai |Angfeng Jiang |Qiao Jin

Simultaneous inhibition of heat shock proteins and autophagy enhances radiofrequency ablation of hepatocellular carcinoma† Radiofrequency ablation (RFA) is a commonly used minimally invasive treatment for hepatocellular carcinoma (HCC). However, incomplete radiofrequency ablation (iRFA) promotes tumor progression and metastasis. There is an urgent need to develop innovative strategies to enhance the efficacy of iRFA.

Dec 29, 2023 | onlinelibrary.wiley.com | Dan Li |Xiaohui Chen |Wenbin Dai |Qiao Jin

The dense extracellular matrix (ECM) in the pancreatic cancer severely hampers the penetration of nanodrugs, which causes inferior therapeutic efficacy. To address this issue, a multifunctional liposome, namely, Lip-DTI/NO, integrating a type-I photosensitizer DTITBT with glutathione (GSH) or heat-responsive nitric oxide (NO) donor S-nitroso-N-acetyl-D-penicillamine (SNAP) is constructed to deplete the tumor ECM, leading to enhanced drug delivery and consequently improved phototherapy.

Dec 2, 2023 | dx.doi.org | Jinchao Zhao |Wenbin Dai |Qiao Jin |Linxing Zhan

RETURN TO ARTICLES ASAPPREVBiological and Medic...Biological and Medical Applications of Materials and InterfacesNEXT Jinchao Zhao Department of Surgery, The Fourth Affiliated Hospital, International Institutes of Medicine, Zhejiang University School of Medicine, Yiwu 322000, China , Wenbin Dai MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310058, China , Linxing Zhan...

Feb 14, 2023 | onlinelibrary.wiley.com | Haitao Hu |Dan Li |Wenbin Dai |Qiao Jin

Abstract Compared to conventional photothermal therapy (PTT) which requires hyperthermia higher than 50 °C, mild-temperature PTT is a more promising antitumor strategy with much lower phototoxicity to neighboring normal tissues. However, the therapeutic efficacy of mild-temperature PTT is always restricted by the thermoresistance of cancer cells.