Wenqi Zhao

2 months ago | nature.com | Wenqi Zhao |Wen Zheng |Zimin Wang |Xiaoli Pan |Gaoting Yang |Zongyi Zhao | +2 more

Alismatis Rhizoma (AR) is widely utilized as a natural medicine across many Asian countries. However, in China, due to its complex origins, AR quality varies, which can affect clinical efficacy. Therefore, there is a need for a method that is both fast and objective to determine the source of AR. In this study, a total of 400 samples of two species and four geographic origins from AR were imaged and processed. From these images, 17 features were extracted, including three shape (S), two color (C), and 12 texture features (T), resulting in a total of 6800 data points. Four commonly used classification models Random Forest (RF), Extreme Learning Machine (ELM), Back Propagation (BP) neural network, and Support Vector Machines (SVM) were tested to find the optimal combination of AR fusion features and classification models. The S + T-RF combinations achieved the best results, with 99.17% accuracy in two species identification and 96.67% accuracy in four geographic origin identification on test sets. These results suggest that image processing combined with the RF model can quickly and effectively identify the complex origins of AR and can provide a reference for the origins identification of other natural medicines.

Aug 19, 2024 | biorxiv.org | Suowen Xu |Zhenghong Liu |Tian Tian |Wenqi Zhao

AbstractObesity is a debilitating disease with increasing worldwide prevalence. Despite its high prevalence, specific pharmacologic intervention for obesity is challenging. Here, we report that halofuginone, an FDA-approved anti-scleroderma and anti-protozoal drug, is a promising anti-obesity agent in rodent models.

Jan 24, 2024 | dx.doi.org | Hao Chen |Wenqi Zhao |Haoyu Feng

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