William R. Schief

Nov 28, 2024 | cell.com | Caterina E. Faliti |Jinyong Choi |Simon Belanger |Christopher M. Tipton |Sakeenah L. Hicks |Maria Cardenas | +17 more

KeywordsantibodiesvaccineCD4 T cellsT follicular helper cellsTfh cellsplasma cellsIL-2 cytokinemTORmetabolismGet full text accessLog in, subscribe or purchase for full access. References1. Radbruch, A. ∙ Muehlinghaus, G. ∙ Luger, E.O. ... Competence and competition: the challenge of becoming a long-lived plasma cellNat. Rev. Immunol. 2006; 6:741-7502. Slifka, M.K. ∙ Antia, R. ∙ Whitmire, J.K. ... Humoral immunity due to long-lived plasma cellsImmunity. 1998; 8:363-3723.

Nov 4, 2023 | nature.com | Ivy Phung |Kristen A. Rodrigues |Ester Marina-Zárate |Bapi Pahar |Wen-Hsin Lee |Pyone P. Aye | +13 more

AbstractAdjuvants and antigen delivery kinetics can profoundly influence B cell responses and should be critically considered in rational vaccine design, particularly for difficult neutralizing antibody targets such as human immunodeficiency virus (HIV). Antigen kinetics can change depending on the delivery method.

Aug 12, 2023 | nature.com | Kristen A. Rodrigues |Chris Cottrell |Yash Agarwal |William R. Schief

AbstractIn the ongoing effort to develop a vaccine against HIV, vaccine approaches that promote strong germinal center (GC) responses may be critical to enable the selection and affinity maturation of rare B cell clones capable of evolving to produce broadly neutralizing antibodies.

Jan 30, 2023 | nature.com | Henry Sutton |Chris Cottrell |Ivy Phung |Gabriel Ozorowski |Jonathan Torres |Wen-Hsin Lee | +10 more

Author notesThese authors contributed equally: Jeong Hyun Lee, Henry J. SuttonAuthors and AffiliationsCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USAJeong Hyun Lee, Henry J. Sutton, Ivy Phung, Catherine Nakao, Kimberly M. Cirelli & Shane CrottyConsortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA, USAJeong Hyun Lee, Henry J. Sutton, Christopher A.