William W. Hannon

Nov 1, 2023 | biorxiv.org | William W. Hannon |Jesse Bloom

AbstractUnderstanding how mutations impact a protein's functions is valuable for many types of biological questions. High-throughput techniques such as deep-mutational scanning (DMS) have greatly expanded the number of mutation-function datasets. For instance, DMS has been used to determine how mutations to viral proteins affect antibody escape, receptor affinity, and essential functions such as viral genome transcription and replication.