Jesse Bloom Journalist Profile

Articles

embo-workshop

Oct 8, 2024 | slides.com | Jesse Bloom

Fred Hutch Cancer Center / HHMIThese slides athttps://slides.com/jbloom/embo-workshopNew variants (mutants) are always arising during viral evolutionCan we predict evolutionary success of viral variants from the biochemical effects of their constituent mutations?
Dynamics and durability of HIV-1 neutralization are determined by viral replication - Nature Medicine

Nov 12, 2023 | nature.com | Philipp Schommers |Dae Sung Kim |Christoph Kreer |Henning Gruell |Elena Knops |Timo Wolf | +10 more

AbstractHuman immunodeficiency virus type 1 (HIV-1)-neutralizing antibodies (nAbs) that prevent infection are the main goal of HIV vaccine discovery. But as no nAb-eliciting vaccines are yet available, only data from HIV-1 neutralizers—persons with HIV-1 who naturally develop broad and potent nAbs—can inform about the dynamics and durability of nAb responses in humans, knowledge which is crucial for the design of future HIV-1 vaccine regimens.
dms-viz: Structure-informed visualizations for deep mutational scanning and other mutation-based datasets

Nov 1, 2023 | biorxiv.org | William W. Hannon |Jesse Bloom

AbstractUnderstanding how mutations impact a protein's functions is valuable for many types of biological questions. High-throughput techniques such as deep-mutational scanning (DMS) have greatly expanded the number of mutation-function datasets. For instance, DMS has been used to determine how mutations to viral proteins affect antibody escape, receptor affinity, and essential functions such as viral genome transcription and replication.
new_2nd_gen_BA2_variant

Aug 16, 2023 | slides.com | Jesse Bloom

New BA.2.86 variant has many spike amino-acid mutations relative to its BA.2 parent, and is an evolutionary jump similar in size to that which originally gave rise to Omicron. Many of these mutations are antigenically important, indicating BA.2.86 variant evolved under strong antibody selection. Deep mutational scanning indicates BA.2.86 variant will have equal or greater escape than XBB.1.5 from antibodies elicited by pre-Omicron and first-generation Omicron variants.
Fitness effects of mutations to SARS-CoV-2 proteins

Jun 6, 2023 | biorxiv.org | Jesse Bloom |Richard Neher

New Results doi: https://doi.org/10.1101/2023.01.30.526314 ABSTRACTKnowledge of the fitness effects of mutations to SARS-CoV-2 can inform assessment of new variants, design of therapeutics resistant to escape, and understanding of the functions of viral proteins.
huanan-market-samples

May 4, 2023 | slides.com | Jesse Bloom

Many samples with the most virus derive their animal genetic material from species that were clearly not infected. No consistent correlation between the SARS-CoV-2 content and genetic material from susceptible species. There are potential confounders that cannot be adequately corrected for, but clearly by time of sampling, the virus was spread widely enough to be co-mingled with material from species that were definitely not infected.
Association between SARS-CoV-2 and metagenomic content of samples from the Huanan Seafood Market

Apr 26, 2023 | biorxiv.org | Jesse Bloom

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Fitness effects of mutations to SARS-CoV-2 proteins

Jan 31, 2023 | biorxiv.org | Jesse Bloom |Richard Neher

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