Won-Ju Kim

Mar 8, 2023 | nature.com | Won-Ju Kim |Caleb A Lareau |Elena Sotillo |Yajie Yin |Alexander Dunn |Ansuman T. Satpathy | +2 more

AbstractAlthough chimeric antigen receptor (CAR) T cells have altered the treatment landscape for B cell malignancies, the risk of on-target, off-tumour toxicity has hampered their development for solid tumours because most target antigens are shared with normal cells1,2. Researchers have attempted to apply Boolean-logic gating to CAR T cells to prevent toxicity3,4,5; however, a truly safe and effective logic-gated CAR has remained elusive6.