Xiao-Hui Yang

Dec 5, 2024 | nature.com | Xiao-Hui Yang

AbstractC(sp3)–Cl bonds are present in numerous biologically active molecules and can also be used as a site for diversification by substitution or cross-coupling reactions. Herein, we report a remote internal site-selective C(sp3)–H bond chlorination of alkenes through sequential alkene isomerization and hydrochlorination, enabling the synthesis of both benzylic and tertiary chlorides with excellent site-selectivity.

Mar 21, 2024 | dx.doi.org | Xiao-Hui Yang |Ryan Davison |Shao-Zhen Nie |Faben Cruz

Thursday, May 09, 2024 Please be aware that pubs.acs.org is undergoing maintenance that may have an impact on your experience. During this time, you may not be able to access certain features like purchasing single articles, saving searches, modifying your e-Alert preferences, or accessing Librarian administrative functions. We appreciate your patience as we continue to improve the ACS Publications platform.

Aug 31, 2023 | chemistry-europe.onlinelibrary.wiley.com | Zhen Wang |Yi-Xin Wang |Xiao-Hui Yang

Corresponding Author Prof. Xiao-Hui Yang Advanced Research Institute of Multidisciplinary Science School of Chemistry and Chemical Engineering Key Laboratory of Medical Molecule Science and Pharmaceutical Engineering, Ministry of Industry and Information Technology Beijing Institute of Technology, Beijing, 100081 P. R. China State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071 P. R. ChinaSearch for more papers by this author

Jun 21, 2023 | chemistry-europe.onlinelibrary.wiley.com | Zhen Wang |Yi-Xin Wang |Xiao-Hui Yang |South Main Street

Abstract Heteroarenes are common moieties in pharmaceuticals and naturally bioactive compounds. Herein, we report an efficient and atom-economic rhodium and thiophenol co-catalyzed hydroheteroarylation of styrenes with heteroarenes. Alkylated unprotected heteroarenes are accessed under low catalyst loading. This protocol provides straightforward access to indoles bearing an all-carbon quaternary center at the C3-position.