Xiaobo Mao

Jul 30, 2024 | nature.com | Xiaobo Mao |Donghoon Kim |Yasuyoshi Kimura |Ning WANG |Enquan Xu |Haibo Wang | +15 more

Correction to: Nature Communications https://doi.org/10.1038/s41467-024-49016-3, published online 31 May 2024The original version of this Article contained an error in Fig. 4, in which the statistical significance for conditions 410C9 versus Lag3−/− in panel 4i was reported as not significant when the association is significant. The correct version of Fig 4 is:Which replaces the previous incorrect version:The original version of this Article contained an error in the figure legend of Fig.

May 20, 2024 | onlinelibrary.wiley.com | Yan Lin |Xiaobo Mao

1 INTRODUCTION Atrial fibrillation (AF) is a common atrial arrhythmia, associated with increased incidence rate and mortality of cardiovascular events.1 AF is associated with an increased risk of thromboembolism and stroke, which is needed to long-term anticoagulant therapy to reduce the risk of stroke. Despite progress and development in anticoagulation strategies, the high risk of bleeding complications and strict medication adherence make treatment more complex.

Jan 1, 2024 | nature.com | Jiakai Hou |Yanjun Wei |Long Sun |Shaoheng Liang |Ashley Guerrero |Xiaobo Mao | +7 more

AbstractHost anti-viral factors are essential for controlling SARS-CoV-2 infection but remain largely unknown due to the biases of previous large-scale studies toward pro-viral host factors. To fill in this knowledge gap, we perform a genome-wide CRISPR dropout screen and integrate analyses of the multi-omics data of the CRISPR screen, genome-wide association studies, single-cell RNA-Seq, and host-virus proteins or protein/RNA interactome.

Aug 6, 2023 | nature.com | Xiaobo Mao

AbstractChronic pain is often associated with cognitive decline, which could influence the quality of the patient’s life. Recent studies have suggested that Toll-like receptor 3 (TLR3) is crucial for memory and learning. Nonetheless, the contribution of TLR3 to the pathogenesis of cognitive decline after chronic pain remains unclear. The level of TLR3 in hippocampal neurons increased in the chronic constriction injury (CCI) group than in the sham group in this study.