Xiaofei Hu

Dec 25, 2024 | mdpi.com | Xiaofei Hu

2.

Jul 24, 2024 | onlinelibrary.wiley.com | Xiaofei Hu |li Liu |Ming Xiong |Jie Lu

1 INTRODUCTION Cerebral small vessel disease (CSVD) refers to a range of clinical, imaging, and pathological syndromes caused by various etiologies that affect the cerebral small arteries, brain venules, and capillaries.

Jun 1, 2024 | bmcgeriatr.biomedcentral.com | Yuan Yuan |Yong Yang |Xiaofei Hu |Lin Zhang |Ying Bai |Jiale Zeng | +2 more

Research the dose–response relationship between overall and certain types of exercise and cognitive function in older adults with Alzheimer's disease and dementia. Systemic and Bayesian Model-Based Network Meta-Analysis. In our study, we analyzed data from randomized controlled trials investigating the effects of different exercises on cognitive outcomes in older adults with AD. We searched the Web of Science, PubMed, Cochrane Central Register of Controlled Trials, and Embase up to November 2023. Using the Cochrane Risk of Bias tool (Rob2) for quality assessment and R software with the MBNMA package for data analysis, we determined standard mean differences (SMDs) and 95% confidence intervals (95%CrI) to evaluate exercise's impact on cognitive function in AD. Twenty-seven studies with 2,242 AD patients revealed a nonlinear relationship between exercise and cognitive improvement in AD patients. We observed significant cognitive enhancements at an effective exercise dose of up to 1000 METs-min/week (SMDs: 0.535, SD: 0.269, 95% CrI: 0.023 to 1.092). The optimal dose was found to be 650 METs-min/week (SMDs: 0.691, SD: 0.169, 95% CrI: 0.373 to 1.039), with AE (Aerobic exercise) being particularly effective. For AE, the optimal cognitive enhancement dose was determined to be 660 METs-min/week (SMDs: 0.909, SD: 0.219, 95% CrI: 0.495 to 1.362). Nonlinear dose–response relationship between exercise and cognitive improvement in Alzheimer’s disease, with the optimal AE dose identified at 660 METs-min/week for enhancing cognitive function in AD.

Dec 3, 2023 | mdpi.com | Muhammad Umair |Xiaofei Hu |Qi Cheng |Shahzad Ali

All articles published by MDPI are made immediately available worldwide under an open access license. No specialpermission is required to reuse all or part of the article published by MDPI, including figures and tables. Forarticles published under an open access Creative Common CC BY license, any part of the article may be reused withoutpermission provided that the original article is clearly cited. For more information, please refer tohttps://www.mdpi.com/openaccess.

Jun 30, 2023 | frontiersin.org | Lipids Metabolism |Cheeloo College |Peter E. Wais |Xiaofei Hu

1. Introduction Cerebral small vessel disease (CSVD) represents a cluster of vascular diseases involving a variety of cerebral vessels, including arterioles, venules, and capillaries; it is believed to be a major factor in dementia, cognitive decline, mood disorders, gait impairment and stroke (Litak et al., 2020).