Xiaohua Zheng

Dec 22, 2024 | mdpi.com | Xiaohua Zheng

1. IntroductionSimilar to chemotherapy and radiotherapy, phototherapy has been proven to be an effective and highly promising therapeutic modality for the treatment of malignant tumors [1,2]. Due to its operational simplicity, cost-effectiveness, and non-invasiveness, phototherapy has consistently attracted the attention of numerous researchers and become an area of in-depth investigation [3]. Phototherapy can be categorized into two primary mechanisms: PDT and PTT [4].

Oct 30, 2024 | pubs.rsc.org | Xiaohua Zheng |Qiuyun Zhang |Xiaohui Wang |Jiayi Chen

Recent progress of porphyrin metal-organic frameworks for combined photodynamic therapy and hypoxia-activated chemotherapy Nanoscale metal-organic frameworks integrated with porphyrins (Por-nMOFs) have emerged as efficient nanoplatforms for photodynamic therapy (PDT), which relies on the conversion of molecular oxygen into cytotoxic singlet oxygen. However, the hypoxic microenvironment within tumors significantly limits the efficacy of PDT.