Xiaohui Zhao

Dec 15, 2023 | mdpi.com | Xiaohui Zhao |Yutong Liu |Yue Cao |Hui cao

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Oct 11, 2023 | mdpi.com | Yutong Liu |Rui Han |Xiaohui Zhao |Yue Cao

This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticleby 1, 1, 1, 1, 1,*, 2,*, 1, 1 and 1 1School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, China2Beijing Engineering Research Center of Printed Electronics, Beijing Institute of Graphic Communication, Beijing, 102600, China*Authors to whom correspondence should be addressed.

May 29, 2023 | nature.com | Xiaohui Zhao |Victor Chen |Matthew Griffin |Luke L. Lairson

AbstractThe microbiota generates diverse metabolites to modulate host physiology and disease, but their protein targets and mechanisms of action have not been fully elucidated. To address this challenge, we explored microbiota-derived indole metabolites and developed photoaffinity chemical reporters for proteomic studies. We identified many potential indole metabolite-interacting proteins, including metabolic enzymes, transporters, immune sensors and G protein-coupled receptors.